Christoph A. Naumann

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Christoph A. Naumann
(317) 278-2512
LD 326R
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Co-Director, Nanoscale Imaging Center
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Education History: 

Diplom, University of Leipzig, 1990

Ph.D., Technical University Munich, 1995

Postdoctoral Fellow, Technical University Munich, 1995-96

Postdoctoral Fellow, Max-Planck-Institute for Polymer Research, Mainz, 1996

Postdoctoral Fellow, Stanford University, 1996-99

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Our first area of interest is the biofunctionalization of inorganic solids and polymeric materials with bioartificial membranes that mimic specific properties of native biomembranes. The biofunctionalization of substrates is of great practical and scientific interest because it not only opens a wide field for studying biochemical processes with surface-sensitive detection techniques but has also several technical applications such as biosensors or biomaterials. Our main goal is a fundamental understanding of the relationship between molecular design and functionality of bioartificial membranes on substrates. Specifically, we are monitoring the movement of single proteins and lipids within the 2-dimensional matrix of bioartificial membranes via single molecule fluorescence imaging microscopy. This will help explain of how the membrane properties are affected by the underlying substrate.

Our second research area has its focus on the structure-function relationship of biomaterials. Biomaterials are synthetic materials, which treat or replace any tissue, organ, or function of the body. The quality of a biomaterial depends on several factors including: its design, its properties, and its acceptance by the surrounding tissue (biocompatibility). One research interest has the goal to obtain a deeper understanding of how chemical and physical properties affect the biocompatibility of potential biomaterials. Our experiments will help develop biomaterials with novel surface properties.

Select Publications: 

K. Lüdtke, R. Jordan, N. Furr, S. Garg, K. Forsythe and C. A. Naumann "2d center-of-mass diffusion of lipid-tethered poly(2-methyl-2- oxazoline) at the air-water interface studied at the single molecule level" Langmuir 2008, 24, in press.

M. J. Murcia, D. L. Shaw, E. C. Long and C. A. Naumann "Fluorescence correlation spectroscopy of CdSe/ZnS quantum dot optical bioimaging probes with ultra-thin biocompatible coatings" Opt. Commun. 2008, 281, 1771-1780.

S. Garg, J. Ruehe, K. Luedtke, R. Jordan and C. A. Naumann "Domain registration in raft-mimicking lipid mixtures studied using polymer- tethered lipid bilayers" Biophys. J. 2007, 92, 1263-1270.

M. J. Murcia, S. Garg and C. A. Naumann "Single molecule fluorescence microscopy to determine phospholipid lateral diffusion" in: Protocols in Biophysics to Study Membrane Lipids, A. Dopico, Ed. Humana Press: Totowa, 2006.

M.J. Murcia, D. L. Shaw, H. Woodruff, C. A. Naumann, B. Young and E. C. Long "Facile sonochemical synthesis of highly luminescent ZnS- shelled CdSe quantum dots" Chem. Mater. 2006, 18, 2219-2225.

M. A. Deverall, E. Gindl, E.-K. Sinner, H. Besir, J. Ruehe, M. J. Saxton and C. A. Naumann "Membrane lateral mobility obstructed by polymer-tethered lipids studied at the single molecule level" Biophys. J. 2005, 88, 1875-1886.

K. Luedtke, R. Jordan, N. O. Hommes, and C. A. Naumann "Lipopolymers from new 2-substituted-2-oxazolines for artificial cell membrane constructs" Macromol. Biosci. 2005, 5, 384-393.

M. J. Murcia and C. A. Naumann "Biofunctionalization of fluorescent nanoparticles" in: Nanotechnologies for Life Sciences, Vol. 1, S. S. R. Kumar, Ed., Wiley-VCH, Weinheim, 2005, pp 1-40.

M. B. Foreman, J. P. Coffman, M. J. Murcia, S. Cesana, R. Jordan, G. S. Smith and C. A. Naumann "Gelation of amphiphilic lipopolymers at the air-water interface: 2D analogue to 3D gelation of colloidal systems with grafted polymer chains" Langmuir 2003, 19, 326-332.

C. A. Naumann, O. Prucker, T. Lehmann, J. Ruehe, W. Knoll and C. W. Frank "The polymer-supported phospholipid bilayer: Tethering as a new approach toward substrate-membrane stabilization" Biomacromolecules 2002, 3, 27-35.

J. P. Coffman and C. A. Naumann "Molecular weight dependence of viscoelastic properties in two-dimensional physical polymer networks of amphiphilic lipopolymer monolayers at the air-water interface" Macromolecules 2002, 35, 1835-1839.

P. C. Ke and C. A. Naumann "Hindered diffusion in polymer-tethered phospholipid monolayers at the air-water interface: A single molecule fluorescence imaging study" Langmuir 2001, 17, 5076-5081.

P. C. Ke and C. A. Naumann "Single molecule fluorescence imaging of phospholipid monolayers at the air-water interface" Langmuir 2001, 17, 3727-3733.

C. W. Frank, C. A. Naumann, W. Knoll, C. F. Brooks and G. G. Fuller "Two-dimensional physical networks of lipopolymers at the air-water interface" Macromolecular Symposia 2001,166, 1-12.

C. A. Naumann, W. Knoll and C. W. Frank "Hindered diffusion in polymer-tethered membranes: A monolayer study at the air-water interface" Biomacromolecules 2001, 2, 1097-1103.

C. A. Naumann, C. F. Brooks, G. G. Fuller, T. Lehmann, J. Ruehe, W. Knoll, P. Kuhn, O. Nuyken and C. W. Frank "Two-dimensional physical networks of lipopolymers at the air-water interface: Correlation of molecular structure and surface rheological behavior" Langmuir 2001, 17, 2801-2806.

C. A. Naumann, C. F. Brooks, W. Wiyatno, G. G. Fuller, W. Knoll and C. W. Frank "Rheological properties of lipopolymer-phospholipid mixtures at the air-water interface: A novel form of two-dimensional physical gelation" Macromolecules 2001, 34, 3024-3032.